2 edition of effect of PSC 833 on the energy metabolism of human MCF-7 ADR and ADR-B breast cancer cells found in the catalog.
effect of PSC 833 on the energy metabolism of human MCF-7 ADR and ADR-B breast cancer cells
Mary Ellen Olsten
|Statement||by Mary Ellen Olsten.|
|The Physical Object|
|Pagination||viii, 46 l. :|
|Number of Pages||46|
ER + breast cancer MCF-7 cells Manuel Rieber*, Mary Strasberg-Rieber IVIC, Tumor Cell Biology Laboratory, Center for Microbiology & Cell Biology Apartado , Caracas A, Venezuela 1. Introduction Breast cancer is an important cause of death in women with prevalence increasingwithage.Hormonereceptorstatusisone of a. The link between cancer and altered metabolism is not new, as many observations made during the early period of cancer biology research identified metabolic changes as a common feature of cancerous tissues (such as the Warburg effect; discussed below) 7. As much of the work in the field to date has focused on rapidly prolif-File Size: KB.
Estrogen receptor-positive MCF-7 human breast cancer cells were cultured with or without various concentrations of the test compounds. The concentration required to inhibit cell proliferation by 50% was determined as measured by the incorporation of [3 H]thymidine into DNA. The experiments were done in triplicate, and the results are averages of three by: Although previously unknown in human lung cancer, PC activation was recently reported in hepatic tumors in rat and in estradiol-stimulated breast cancer cells. PC expression or suppression has also been respectively associated with enhanced metabolism/proliferation of mammalian cells [ 41 ] or inhibition of tumor cell growth [ 42 ].Cited by:
Introduction. The long-term survival rate among patients with breast cancer across Europe is >70% ().This rate is, in part, due to the widespread use of post-surgery adjuvant anthracycline-based chemotherapy to treat early-stage breast cancer to reduce the risk of relapse and mortality ().The major anthracycline chemotherapeutic reagent is doxorubicin (DOX), a Streptomyces by: 2. cycle progression and tumor growth in MDA-MB human breast cancer cells. However, it is not clear whether this compound exerts other anticancer effects. The results demostrated that synthetic Cam B can inhibit the anchorage-independent growth of MDA-MB breast cancer cells.
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Effects of amiodarone, cyclosporin A, and PSC on the cytotoxicity of mitoxantrone, doxorubicin, and vincristine in non-P-glycoprotein human small cell lung cancer cell lines. The mechanism underlying the differential cytotoxicity of curcumin in various cancer types, however, remains largely unclear.
The aims of this study is to examine the concentration- and time-related effects of curcumin on two different breast cancer cells, MCF-7 and MDA-MB, and investigated the functional changes induced by curcumin treatment, as well as their relationship to the Cited by: Human breast cancer MCF-7 cells, obtained from Chinese Academy of Sciences cell library, were cultured in Dul- becco’s modiﬁed Eagle’s medium (Hyclone, Thermo Sci.
(HE, HE and HE) on MCF-7 human breast cancer cells. Material and Methods: MCF-7 cells were treated with different concentrations of piperine derivatives (0 Œ 10 μM) during 24h after 48h of cell seeding ( cells/mL).
Results and Discussion: Cell viability assay with MTT, showed that cell growth was dose dependent. However, studies investigating the effect of chemotherapy on the metabolism of breast cancer cells are still limited.
We used 1 H high-resolution magic angle spinning (HR-MAS) NMR spectroscopy to study the metabolic profile of human breast cancer MDA-MB cells either untreated (control) or treated with tamoxifen, cisplatin, and by: 7.
It was found that the IC 50 values of ADR to MCF-7 cells were much lower than those to MCF-7/ADR cells and the values decreased with the treating time extension. GQ reduced the IC 50 of ADR to both cell lines, but its effect on MCF-7/ADR cells was much stronger than that on MCF-7 cells (Fig.
2 B).Author: Enxia Zhang, Jiasi Liu, Lei Shi, Xin Guo, Ze Liang, Jiaxin Zuo, Hong Xu, Huaxin Wang, Xiaohong Shu. Differences in energy metabolism between normal and cancer cells are reported andalterations in cellular bioenergetics are one of the hallmarks of cancer .The general principles of metabolic control analysis can be effective for cancer management as abnormal energy metabolism and biological disorder are characteristics of tumors .In line with this, increased aerobic glycolysis and elevated Cited by: 9.
Tumor therapy mainly attacks the metabolism to interfere the tumor's anabolism and signaling of proliferative second messengers. However, the metabolic demands of different cancers are very heterogeneous and depend on their origin of tissue, age, gender and other clinical parameters.
We investigated tumor specific regulation in the metabolism of breast by: Introduction. Gastric cancer (GC) is one of the most common human cancers and the second leading cause of cancer-related mortality worldwide ().The major cause of death is metastasis, which greatly hinders treatment success ().Human gastric cancer tissue contains cancer initiating cells (CIC) ().CIC are defined as the unique subpopulation in the tumors that possess the ability to initiate Cited by: 2.
We found that ΔFosB increased the expression of MMP-9 in MCF-7 breast cancer cells. ΔFosB overexpression in MCF-7 cells increased cellular viability and decreased cell apoptosis.
SB-3CT, an inhibitor of MMP-9, promoted apoptosis, inhibited cell proliferation, induced cell cycle arrest, and downregulated the expression of antiapoptotic genes Bcl-2 and Bcl-xl in MCF-7 by: 5. Mary Ellen Olsten has written: 'The effect of PSC on the energy metabolism of human MCF-7 ADR and ADR-B breast cancer cells'.
To investigate the quantitative response of energy metabolic pathways in human MCF-7 breast cancer cells to hypoxia, glucose deprivation, and estradiol stimulation, we developed a targeted proteomics assay for accurate quantification of protein expression in glycolysis/gluconeogenesis, TCA cycle, and pentose phosphate by: In the MCF-7 breast cancer cell line, mTOR activity is thought to be responsible for the constitutive activity of Akt, and inhibition of mTOR activity restores response to the antiestrogen by: EMMPRIN and MCF-7 breast cancer cells Genetics and Molecular Research 14 (4): () ©FUNPEC-RP abnormalities.
Cells in the G0/G1 and G2/M phases were increased, while cells in the S phase were decreased after infection of MCF-7 cells for 3 days. The EMMPRIN gene facilitates breast cancer cell.
Mary Ellen Olsten has written: 'The effect of PSC on the energy metabolism of human MCF-7 ADR and ADR-B breast cancer cells' Asked in Genealogy What does ADR stand for in genealogy. AdipoR1 to assess this. Then, human breast cancer cell line MCF-7 was cultured in the absence or presence of the mimics or inhibitors of miR, after which the biological functions of MCF-7 cells were analyzed.
The protein expression of AdipoR1, AMPK, and SIRT-1 were examined. The interaction between AdipoR1 and Flotillin-1, or itsCited by: 1.
The paradoxical effects of ovarian hormones in both the promotion and prevention of breast cancer have been debated for over 30 years. Genetic studies have demonstrated that ovarian hormones act through NF-κB to stimulate proliferation and ductal elongation, whereas the p53 tumor suppressor protein plays a central role in rendering the mammary epithelium resistant to by: Review Article Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer Meena K.
Sakharkar, 1 Babita Shashni, 1 Karun Sharma, 1 Sarinder K. Dhillon, 2 Prabhakar R. Ranjekar, 3 and Kishore R. Sakharkar 4,5 Graduate School of Life and Environmental Sciences, Univers ity of Tsukuba, Tennoudai -- Tsukuba - Japan.
Anti-Proliferative Effects in Human Breast Cancer MDA. MCF-7 Cells & Human Breast Epithelial MCFa Cells and Western Blot Analysis from Adlay (Coix Lacryma-Jobi L.) Varieties Phenolic ExtractsLifeng Wang 1, 2, Huihui Xie 1, Yumei Wang 1, Ruihai Liu 2 and Xingrong Ju 1.
1 School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, Jiangsu PR, ChinaCited by: 1. Effect of PPARγ and MAZ shRNAs applications on down-regulation of PPARγ1 expression and activity in the MCF-7 breast cancer cell test the specificity of MAZ and PPARγ shRNAs for their target genes and estimate the efficiency of MAZ and PPARγ knock-down, Real-time PCR analysis of MCF-7 cells transfected with scrambled, MAZ, or PPARγ shRNA was by:.
Alcohol consumption is a risk factor for breast cancer. Little is known regarding the mechanism, although it is assumed that acetaldehyde or estrogen mediated pathways play a role.
We previously showed that long-term exposure to mM ethanol (blood alcohol ~%) of MCFA, a human normal epithelial breast cell line, induced epithelial.karyotype contractions (KC) allow cancer cells to support fewer chromosomes, increase their proliferation rate and acquire the phenotype of a stable, growing tissue similar to stem cells.
Hyperploid cancer cells can expand or contract their karyotypes through rapid mechanisms of endo-reduplication or chromosome : Ying Li.Numerous transcriptomics and cistromics studies were done to investigate estrogen signaling and gene regulation in breast cancer cells, including MCF7 cells 2, In this study, for the first time, we added metabolomics data and tried to infer metabolic networks that are directly regulated by .